CEDARWOOD OIL
CASRN: 8000-27-9
For other data, click on the Table of Contents

Human Health Effects:

Human Toxicity Excerpts:

HAS BEEN USED TO PRODUCE ABORTION, IN SOME CASES WITH A FATAL OUTCOME.
[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-231]**PEER REVIEWED**

A maximization test was carried out on 25 volunteers. The material was tested at a concn of 8% in petrolatum and produced no sensitization reactions. Patch tests were used to investigate "cedar-poisoning" in 43 persons exposed to wood products or vegetation. The results...obtained showed /no sensitivity to cedarwood oils/. ... No phototoxic effects were reported for cedarwood oil.
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 201]**PEER REVIEWED**

Tested at 8% in petrolatum, it produced no irritation after a 48-hr closed-patch test on human subjects. A maximization test was carried out on 25 volunteers. The material was tested at a concn of 8% in petrolatum and produced no sensitization reactions. /Cedarwood oil atlas/
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 198]**PEER REVIEWED**

Tested at 8% in petrolatum, it produced no irritation after a 48-hr closed-patch test on human subjects. A maximization test was carried out on 25 volunteers. The material was tested at a concn of 8% in petrolatum and produced no sensitization reactions. /Cedarwood oil Texas/
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 199]**PEER REVIEWED**

 

Emergency Medical Treatment:

 

 

Emergency Medical Treatment:

 

EMT Copyright Disclaimer:
Portions of the POISINDEX(R) database are provided here for general reference. THE COMPLETE POISINDEX(R) DATABASE, AVAILABLE FROM MICROMEDEX, SHOULD BE CONSULTED FOR ASSISTANCE IN THE DIAGNOSIS OR TREATMENT OF SPECIFIC CASES. Copyright 1974-1998 Micromedex, Inc. Denver, Colorado. All Rights Reserved. Any duplication, replication or redistribution of all or part of the POISINDEX(R) database is a violation of Micromedex' copyrights and is strictly prohibited.

The following Overview, *** IRRITANTS ***, is relevant for this HSDB record chemical.

Life Support:
  o   This overview assumes that basic life support measures
      have been instituted.                           
Clinical Effects:
  SUMMARY OF EXPOSURE
   0.2.1.1 ACUTE EXPOSURE
     o   Whether a substance is labeled a "corrosive" or
         "irritant" depends on several factors:  the nature of
         the substance, concentration, viscosity, pH, molarity,
         oxidation-reduction potential, complexing affinity
         toward bivalent ions etc.  It is difficult to determine
         if a substance is a corrosive or irritant at a
         particular concentration.
     o   Irritants are substances that cause inflammation and
         swelling, but not cellular death and tissue damage.  A
         corrosive would cause cellular damage and death.
      1.  Inhalation exposure may result in headache; nasal
          dryness and hemorrhage; and glottic, esophageal, or
          pulmonary edema.
  HEENT
   0.2.4.1 ACUTE EXPOSURE
     o   Irritants may cause swelling, redness and pain at any
         site, especially at mucous membranes.  The mouth, nose,
         and eyes are susceptible to these effects.
  RESPIRATORY
   0.2.6.1 ACUTE EXPOSURE
     o   Cough, tachypnea, and wheezing are common after
         inhalation.
  GASTROINTESTINAL
   0.2.8.1 ACUTE EXPOSURE
     o   Nausea, vomiting and diarrhea are possible if ingested.
  DERMATOLOGIC
   0.2.14.1 ACUTE EXPOSURE
     o   Redness, swelling and pain may occur.
  CARCINOGENICITY
   0.2.21.2 HUMAN OVERVIEW
     o   Development of sinonasal neoplasms has been associated
         with exposure to wood dust and other irritants.
Laboratory:
  o   No specific laboratory tests are necessary with the
      possible exception of testing the pH of the irritant
      substance, and the pH of the ocular cul de sac with wide
      range pH paper.                                          
Treatment Overview:
  SUMMARY EXPOSURE
    o   Life Support - Support respiratory and cardiovascular
        function.
    o   Dilution and irrigation should be primary
        considerations.  Systemic symptoms are unlikely.
  ORAL EXPOSURE
    o   EMESIS - Not indicated due to the irritant nature of
        these agents.
    o   Charcoal and Cathartic - Are seldom recommended.  They
        may promote vomiting and make endoscopic evaluation
        difficult.
    o   DILUTION - Immediate therapy should be dilution with
        water in copious amounts.  Do not exceed 15 mL/kg orally
        in a child (maximum 250 mL in a 16 kg or larger patient)
        as vomiting may occur with excessive fluids.
    o   NEUTRALIZATION - Neutralization is not indicated.
    o   Although these agents are irritants, and therefore
        should not produce tissue damage, it is almost
        impossible to assure that a particular substance under a
        particular set of circumstances would not cause damage.
        Therefore, each patient should be examined with the idea
        that mucous membrane damage might have occurred.
  INHALATION EXPOSURE
    o   INHALATION:  Move patient to fresh air.  Monitor for
        respiratory distress.  If cough or difficulty breathing
        develops, evaluate for respiratory tract irritation,
        bronchitis, or pneumonitis.  Administer oxygen and
        assist ventilation as required.  Treat bronchospasm with
        beta2  agonist and corticosteroid aerosols.
  EYE EXPOSURE
    o   DECONTAMINATION:  Irrigate exposed eyes with copious
        amounts of tepid water for at least 15 minutes.  If
        irritation, pain, swelling, lacrimation, or photophobia
        persist, the patient should be seen in a health care
        facility.
    o   If in a medical facility, sterile saline should be used
        to irrigate the eyes until the cul de sac is returned to
        neutrality.  Some alkali exposures may require prolonged
        irrigation.
Range of Toxicity:
  o   The extent of damage will depend on a number of factors
      including concentration, mechanism of action, pH, free
      acidity and alkalinity, molarity and oxidation-reduction
      potential.  In most cases these factors are more important
      than volume.  Besides its irritant effect, a substance may
      also have some type of systemic effect.  Observe for any
      potential systemic effects, as is appropriate for each
      compound.                                            


[Rumack BH: POISINDEX(R) Information System. Micromedex, Inc., Englewood, CO, 2001; CCIS Volume 110, edition exp November, 2001. Hall AH & Rumack BH (Eds):TOMES(R) Information System. Micromedex, Inc., Englewood, CO, 2001; CCIS Volume 110, edition exp November, 2001.] **PEER REVIEWED**

 

EMT Copyright Disclaimer:
Portions of the POISINDEX(R) database are provided here for general reference. THE COMPLETE POISINDEX(R) DATABASE, AVAILABLE FROM MICROMEDEX, SHOULD BE CONSULTED FOR ASSISTANCE IN THE DIAGNOSIS OR TREATMENT OF SPECIFIC CASES. Copyright 1974-1998 Micromedex, Inc. Denver, Colorado. All Rights Reserved. Any duplication, replication or redistribution of all or part of the POISINDEX(R) database is a violation of Micromedex' copyrights and is strictly prohibited.

The following Overview, *** GENERAL OR UNKNOWN CHEMICAL ***, is relevant for this HSDB record chemical.

Life Support:
  o   This overview assumes that basic life support measures
      have been instituted.                           
Clinical Effects:
  SUMMARY OF EXPOSURE
   0.2.1.1 ACUTE EXPOSURE
     o   A SPECIFIC REVIEW on the clinical effects and treatment
         of individuals exposed to this agent HAS NOT YET BEEN
         PREPARED.  The following pertains to the GENERAL
         EVALUATION and TREATMENT of individuals exposed to
         potentially toxic chemicals.
     o   GENERAL EVALUATION -
      1.  Exposed individuals should have a careful, thorough
          medical history and physical examination performed,
          looking for any abnormalities.  Exposure to chemicals
          with a strong odor often results in such nonspecific
          symptoms as headache, dizziness, weakness, and nausea.
     o   IRRITATION -
      1.  Many chemicals cause irritation of the eyes, skin, and
          respiratory tract.  Respiratory tract irritation, if
          severe, can progress to pulmonary edema, which may be
          delayed in onset for up to 24 to 72 hours in some
          cases.
      2.  Irritation or burns of the esophagus or
          gastrointestinal tract are also possible if caustic or
          irritant chemicals are ingested.
     o   HYPERSENSITIVITY -
      1.  A number of chemical agents produce an allergic
          hypersensitivity dermatitis or asthma with
          bronchospasm and wheezing with chronic exposure.
Laboratory:
  o   A number of chemicals produce abnormalities of the
      hematopoietic system, liver, and kidneys.  Monitoring
      complete blood count, urinalysis, and liver and kidney
      function tests is suggested for patients with significant
      exposure.
  o   If respiratory tract irritation or respiratory depression
      is evident, monitor arterial blood gases, chest x-ray, and
      pulmonary function tests.                 
Treatment Overview:
  SUMMARY EXPOSURE
    o   A specific review on the clinical effects and treatment
        of individuals exposed to this agent has not yet been
        prepared.  The following pertains to the general
        evaluation and treatment of individuals exposed to
        potentially toxic chemicals.
    o   Move victims of inhalation exposure from the toxic
        environment and administer 100% humidified supplemental
        oxygen with assisted ventilation as required.  Exposed
        skin and eyes should be copiously flushed with water.
     1.  Rescuers must not enter areas with potential high
         airborne concentrations of this agent without
         SELF-CONTAINED BREATHING APPARATUS (SCBA) to avoid
         becoming secondary victims.
    o   Measures to decrease absorption may be useful.  The
        decision to induce or not to induce emesis in ingestions
        must be carefully considered.  If the patient has any
        signs of esophageal or gastrointestinal tract irritation
        or burns, or has evidence of a decreased sensorium, a
        depressed gag reflex, or impending shock, INDUCED EMESIS
        SHOULD BE AVOIDED.
  ORAL EXPOSURE
    o   GASTRIC LAVAGE
     1.  Significant esophageal or gastrointestinal tract
         irritation or burns may occur following ingestion.  The
         possible benefit of early removal of some ingested
         material by cautious gastric lavage must be weighed
         against potential complications of bleeding or
         perforation.
     2.  GASTRIC LAVAGE:  Consider after ingestion of a
         potentially life-threatening amount of poison if it can
         be performed soon after ingestion (generally within 1
         hour).  Protect airway by placement in Trendelenburg
         and left lateral decubitus position or by endotracheal
         intubation.  Control any seizures first.
      a.  CONTRAINDICATIONS:  Loss of airway protective reflexes
          or decreased level of consciousness in unintubated
          patients; following ingestion of corrosives;
          hydrocarbons (high aspiration potential); patients at
          risk of hemorrhage or gastrointestinal perforation;
          and trivial or non-toxic ingestion.
    o   ACTIVATED CHARCOAL
     1.  Activated charcoal binds most toxic agents and can
         decrease their systemic absorption if administered soon
         after ingestion.  In general, metals and acids are
         poorly bound and patients ingesting these materials
         will not likely benefit from activated charcoal
         administration.
      a.  Activated charcoal should not be given to patients
          ingesting strong acidic or basic caustic chemicals.
          Activated charcoal is also of unproven value in
          patients ingesting irritant chemicals, where it may
          obscure endoscopic findings when the procedure is
          justified.
     2.  ACTIVATED CHARCOAL:  Administer charcoal as slurry (240
         mL water/30 g charcoal).  Usual dose:  25 to 100 g in
         adults/adolescents, 25 to 50 g in children (1 to 12
         years), and 1 g/kg in infants less than 1 year old.
    o   DILUTION -
     1.  Immediate dilution with milk or water may be of benefit
         in caustic or irritant chemical ingestions.
     2.  DILUTION:  Following ingestion and/or prior to gastric
         evacuation, immediately dilute with 4 to 8 ounces (120
         to 240 mL) of milk or water (not to exceed 15 mL/kg in
         a child).
    o   IRRITATION -
     1.  Observe patients with ingestion carefully for the
         possible development of esophageal or gastrointestinal
         tract irritation or burns.  If signs or symptoms of
         esophageal irritation or burns are present, consider
         endoscopy to determine the extent of injury.
    o   OBSERVATION CRITERIA -
     1.  Carefully observe patients with ingestion exposure for
         the development of any systemic signs or symptoms and
         administer symptomatic treatment as necessary.
     2.  Patients symptomatic following exposure should be
         observed in a controlled setting until all signs and
         symptoms have fully resolved.
  INHALATION EXPOSURE
    o   DECONTAMINATION -
     1.  INHALATION:  Move patient to fresh air.  Monitor for
         respiratory distress.  If cough or difficulty breathing
         develops, evaluate for respiratory tract irritation,
         bronchitis, or pneumonitis.  Administer oxygen and
         assist ventilation as required.  Treat bronchospasm
         with beta2  agonist and corticosteroid aerosols.
    o   IRRITATION -
     1.  Respiratory tract irritation, if severe, can progress
         to pulmonary edema which may be delayed in onset up to
         24 to 72 hours after exposure in some cases.
    o   PULMONARY EDEMA/NON-CARDIOGENIC -
     1.  PULMONARY EDEMA (NONCARDIOGENIC):  Maintain ventilation
         and oxygenation and evaluate with frequent arterial
         blood gas or pulse oximetry monitoring.  Early use of
         PEEP and mechanical ventilation may be needed.
    o   BRONCHOSPASM -
     1.  If bronchospasm and wheezing occur, consider treatment
         with inhaled sympathomimetic agents.
    o   OBSERVATION CRITERIA -
     1.  Carefully observe patients with inhalation exposure for
         the development of any systemic signs or symptoms and
         administer symptomatic treatment as necessary.
     2.  Patients symptomatic following exposure should be
         observed in a controlled setting until all signs and
         symptoms have fully resolved.
  EYE EXPOSURE
    o   DECONTAMINATION:  Irrigate exposed eyes with copious
        amounts of tepid water for at least 15 minutes.  If
        irritation, pain, swelling, lacrimation, or photophobia
        persist, the patient should be seen in a health care
        facility.
  DERMAL EXPOSURE
    o   DERMAL DECONTAMINATION -
     1.  DECONTAMINATION:  Remove contaminated clothing and wash
         exposed  area thoroughly with soap and water.  A
         physician may need to  examine the area if irritation
         or pain persists.
    o   PESTICIDES -
     1.  DECONTAMINATION:  Remove contaminated clothing and
         jewelry.  Wash  the skin, including hair and nails,
         vigorously; do repeated soap washings.  Discard
         contaminated clothing.
    o   IRRITATION -
     1.  Treat dermal irritation or burns with standard topical
         therapy.  Patients developing dermal hypersensitivity
         reactions may require treatment with systemic or
         topical corticosteroids or antihistamines.
    o   DERMAL ABSORPTION -
     1.  Some chemicals can produce systemic poisoning by
         absorption through intact skin.  Carefully observe
         patients with dermal exposure for the development of
         any systemic signs or symptoms and administer
         symptomatic treatment as necessary.  
Range of Toxicity:
  o   No specific range of toxicity can be established for the
      broad field of chemicals in general.          


[Rumack BH: POISINDEX(R) Information System. Micromedex, Inc., Englewood, CO, 2001; CCIS Volume 110, edition exp November, 2001. Hall AH & Rumack BH (Eds):TOMES(R) Information System. Micromedex, Inc., Englewood, CO, 2001; CCIS Volume 110, edition exp November, 2001.] **PEER REVIEWED**

 

Animal Toxicity Studies:

 

 

Non-Human Toxicity Excerpts:

ABILITY OF CEDAR ENVIRONMENT TO STIMULATE LIVER DRUG-METABOLIZING ENZYMES IN MICE WAS CONFIRMED BY LOWERED VALUES FOR BARBITURATE SLEEPING TIME. CEDAR AND SOME OF ITS DERIVATIVES (OIL OF CEDARWOOD) DISRUPTED THE REPRODUCTIVE AND DEVELOPMENTAL CYCLE OF A NUMBER OF INSECTS, INCL THE PEANUT TRASH BUG, THE INDIAN MEAL MOTH AND THE FORAGE MITE.
[SABINE JR; TOXICOLOGY 5 (2): 221-35 (1975)]**PEER REVIEWED**

Undiluted cedarwood oil Virginia applied to the backs of hairless mice was not irritating. Applied full strength to intact or abraded rabbit skin for 24 hr under occlusion, it was moderately irritating.
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 201]**PEER REVIEWED**

Undiluted cedarwood oil Atlas applied to the backs of hairless mice and swine was not irritating but applied to intact or abraded rabbit skin for 24 hr under occlusion it was slightly irritating. ... No photoxic effects were reported for undiluted cedarwood oil atlas on hairless mice and swine. /Cedarwood oil Atlas/
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 198]**PEER REVIEWED**

Undiluted cedarwood oil Texas was not irritating when applied to the backs of hairless mice and swine or to intact or abraded rabbit skin for 24 hr under occlusion. ... No photoxic effects were reported for undiluted cedarwood oil Texas on hairless mice and swine. /Cedarwood oil Texas/
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 199]**PEER REVIEWED**

 

Metabolism/Pharmacokinetics:

 

 

Pharmacology:

 

 

Environmental Fate & Exposure:

 

 

Natural Pollution Sources:

WOOD OF... JUNIPERUS MEXICANA, JUNIPERUS PROCERA, OR CEDRUS ATLANTICA
[SRI]**PEER REVIEWED**

FROM WOOD OF JUNIPERUS VIRGINIANA L, PINACEAE & OTHER SPECIES OF CEDAR...
[The Merck Index. 10th ed. Rahway, New Jersey: Merck Co., Inc., 1983. 973]**PEER REVIEWED**

 

Environmental Standards & Regulations:

 

 

FIFRA Requirements:

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Cederwood oil is found on List C. Case No: 3150; Pesticide type: insecticide, fungicide; Case Status: RED Approved 09/93; OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Cedarwood oil; Data Call-in (DCI) Date(s): 01/25/94; AI Status: OPP has completed a Reregistration Eligibility Decision (RED) document for the case/AI.
[USEPA/OPP; Status of Pesticides in Registration, Reregistration and Special Review p.285 (Spring, 1998) EPA 738-R-98-002]**QC REVIEWED**

 

FDA Requirements:

/Cedarwood oil alcohols/ is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: 1) the quantity added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) when intended for use in or on food it is of appropriate food grade and is prepared and handled as a food ingredient. /Cedarwood oil alcohols/
[21 CFR 172.515 (4/1/93)]**PEER REVIEWED**

/Cedarwood oil terpenes/ is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: 1) the quantity added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) when intended for use in or on food it is of appropriate food grade and is prepared and handled as a food ingredient. /Cedarwood oil terpenes/
[21 CFR 172.515 (4/1/93)]**PEER REVIEWED**

 

Chemical/Physical Properties:

 

Molecular Formula:

UNKNOWN
**PEER REVIEWED**

 

Color/Form:

COLORLESS OR SLIGHTLY YELLOW LIQUID
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1073]**PEER REVIEWED**

 

Odor:

INCENSE, FRAGRANT & CHAMOMILE
[Merory, J. Food Flavorings: Composition, Manufacture, and Use. 2nd ed. Westport, Conn.: Avi Publishing Co., 1968. 92]**PEER REVIEWED**

 

Taste:

BITTER-SWEET TASTE
[Merory, J. Food Flavorings: Composition, Manufacture, and Use. 2nd ed. Westport, Conn.: Avi Publishing Co., 1968. 92]**PEER REVIEWED**

 

Density/Specific Gravity:

0.940-0.950 @ 20 DEG/20 DEG C
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1073]**PEER REVIEWED**

 

Solubilities:

INSOL IN WATER; SOL IN ETHER; IN 10-20 VOL 90% ALCOHOL
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1073]**PEER REVIEWED**

 

Spectral Properties:

SPECIFIC OPTICAL ROTATION: -25 TO -46 DEG @ 20 DEG C/D; INDEX OF REFRACTION: 1.495-1.510 @ 20 DEG C/D
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1073]**PEER REVIEWED**

 

Other Chemical/Physical Properties:

SOMEWHAT VISCID LIQUID
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1073]**PEER REVIEWED**

Yellow to brownish, slightly viscous liquid with a sweet aromatic odor and a lasting, woody undertone /Atlas cedar wood oil/
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present.,p. VA11 219]**PEER REVIEWED**

Density: 0.925-0.940 @ 25 deg C/25 deg C; Index of refraction: 1.5060-1.5160 at 20 deg C/D; Specific optical rotation: +50 to +77 deg; Solubility: 1 vol in at least 5 vol of 95% ethanol /Atlas cedar wood/
[Environmental Protection Agency/OPTS. Suspended, Cancelled, and Restricted Pesticides. 5th Ed. Washington, DC: Environmental Protection Agency, February 1990.,p. VA11 219]**PEER REVIEWED**

Brown to reddish-brown viscous liquid /Texas cedarwood oil/
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present.,p. VA11 219]**PEER REVIEWED**

Density: 0.954-0.967 @ 25 deg C/25 deg C; Index of refraction: 1.5050-1.5080 at 20 deg C/D; Specific optical rotation: -50 to -35 deg; Solubility: 1 vol in 5 vol of 90% ethanol at 20 deg C /Texas cedarwood oil/
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present.,p. VA11 219]**PEER REVIEWED**

Light yellow to pale brown, viscous liquid /Virginia cedarwood oil/
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present.,p. VA11 219]**PEER REVIEWED**

Density: 0.939-0.958 @ 25 deg C/25 deg C; Index of refraction: 1.5020-1.5100 at 20 deg C/D; Specific optical rotation: -45 to -22.5 deg; Solubility: 1 vol in 0.5-5 vol of 90% ethanol /Virginia cedarwood oil/
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present.,p. VA11 219]**PEER REVIEWED**

 

Chemical Safety & Handling:

 

 

Fire Potential:

SLIGHT; WHEN HEATED.
[Sax, N.I. Dangerous Properties of Industrial Materials. 6th ed. New York, NY: Van Nostrand Reinhold, 1984. 655]**PEER REVIEWED**

 

Storage Conditions:

KEEP WELL CLOSED, COOL & PROTECTED FROM LIGHT.
[The Merck Index. 10th ed. Rahway, New Jersey: Merck Co., Inc., 1983. 973]**PEER REVIEWED**

 

Disposal Methods:

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
**PEER REVIEWED**

 

Occupational Exposure Standards:

 

 

Manufacturing/Use Information:

 

 

Major Uses:

IN FURNITURE POLISH
[Arena, J.M. Poisoning: Toxicology-Symptoms Treatments. Third Edition. Springfield, Illinois: Charles C. Thomas, 1974. 199]**PEER REVIEWED**

FRAGRANCE INGREDIENT (MODIFIER OF OTHER OILS) IN SOAPS, IN PERFUMES; RAW MATERIAL FOR ALCOHOLS & TERPENES AS FLAVORINGS; INSECT REPELLENT; CLEARING AGENT IN MICROSCOPY; AGENT IN OIL IMMERSION MICROSCOPY
[SRI]**PEER REVIEWED**

As insect repellant; the thickened oil is used in microscopy as a clearing agent and for use with immersion lenses.
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1073]**PEER REVIEWED**

In soap perfumes
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present.,p. VA11 219]**PEER REVIEWED**

Perfuming soap and other products, as a starting material for the isolation of cedrol...and other valuable fragrance materials.
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present.,p. VA11 219]**PEER REVIEWED**

To convey woody notes to fragrances and also of fixatives.
[Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984.,p. V16 322]**PEER REVIEWED**

IN MFR OF CARTRIDGES USED TO PRODUCE SMOKE IN ELECTRIC TOY TRAINS. CARTRIDGES USED CONTAIN META-TERPHENYL OR KEROSENE & CEDAR WOOD OIL.
[Arena, J.M. Poisoning: Toxicology-Symptoms Treatments. Third Edition. Springfield, Illinois: Charles C. Thomas, 1974. 700]**PEER REVIEWED**

 

Manufacturers:

INTERNATIONAL FLAVORS & FRAGRANCES, HAZLET, NJ 07730, UNION BEACH, NJ 07735
[SRI]**PEER REVIEWED**

MONSANTO CO, MONSANTO FLAVOR/ESSENCE, INC, PATCHOGUE, NY 11772
[SRI]**PEER REVIEWED**

RHODIA INC, CHEM DIV, NEW YORK, NY 10022
[SRI]**PEER REVIEWED**

 

Methods of Manufacturing:

STEAM DISTILLATION OF SAWDUST OR FINELY CHOPPED WOOD OF JUNIPERUS VIRGINIANA...
[SRI]**PEER REVIEWED**

/WITH/ CEDRENE (A TERPENE) & CEDRAL (CEDAR CAMPHOR) /AS CHIEF CONSTITUENTS/.
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1073]**PEER REVIEWED**

EXTRACTION OF CEDARWOOD WITH PETROLEUM ETHER OR ETHYL ALCOHOL FOLLOWED BY REMOVAL OF SOLVENT & VACUUM DISTILLATION PROVIDED 18.6 & 21.7% YIELDS COMPARED TO 7.5% FOR STEAM DISTILLATION.
[SINGH T ET AL; PARFUEM KOSMET 57 (3): 68-71 (1976)]**PEER REVIEWED**

 

General Manufacturing Information:

The main constituents of cedarwood oil Virginia are cedrene, thujopsene and cedrol.
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 201]**PEER REVIEWED**

The chief constituents of cedarwood oil atlas are alpha- and gamma-atlantone. The essential oil of Cedrus atlantica contains alpha-ionone, alpha-caryophyllene alcohol, epi-beta-cubenol, epoxy-beta-himachalene and its epimer, deodarone, and a new ketone. /Cedarwood oil atlas/
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 198]**PEER REVIEWED**

The main constituents of cedarwood oil Texas include cedrene, cedrol and pseudocedrol. /Cedarwood oil Texas/
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 199]**PEER REVIEWED**

A low concentration of cedarwood oil (0.4452%) was sufficient in knocking down 50% of Anopheles stephensi after 6 hours.
[Singh D et al; Naturwissenschaften 71 (5): 265-6 (1984)]**PEER REVIEWED**

Cedarwood oil Texas is not included in the listings of the FDA, FEMA (1965) or the Council of Europe (1974) or in the Foods Chemicals Codex (1972). /Cedarwood oil Texas/
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 199]**PEER REVIEWED**

Several different conifer species are called cedars and the corresponding oils vary considerably in composition
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present.,p. VA11 219]**PEER REVIEWED**

A wide variety of cedarwood oils (58-60) are produced
[Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984.,p. V16 322]**PEER REVIEWED**

Cedarwood oil atlas is not included in the listings of the FDA, FEMA (1965) or the Council of Europe (1974) or in the Foods Chemicals Codex (1972). /Cedarwood oil atlas/
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 198]**PEER REVIEWED**

The Council of Europe (1970) included cedarwood oil Virginia (Juniperus virginiana) in the list of flavoring substances temporarily admitted for use, possibly with a limitation on the active principle in the final product.
[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979. 201]**PEER REVIEWED**

Obtained by steam distillation of wood /Atlas, Chinese, and Texas cedarwood oils/
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present.,p. VA11 219]**PEER REVIEWED**

Obtained by steam distillation of sawdust, finely chipped waste wood from the manufacture of cedarwood products, or from stumps and logs of the red cedar /Virginia cedarwood oil/
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present.,p. VA11 219]**PEER REVIEWED**

Consumption Patterns:

MORE THAN 4.54X10+7 GRAMS AS A FRAGRANCE INGREDIENT (1972)
[SRI]**PEER REVIEWED**

Laboratory Methods:

Analytic Laboratory Methods:

A gas chromatographic analysis method for determining the presence of cedarwood oil is described.
[Singh T; Gas Chromatographic Analysis. Parfuem Kosmet 57 (3): 68-71 (1976)]**PEER REVIEWED**

Special References:

Special Reports:

Ramachandraiah OS et al; Studies in Indian Essential Oils. Deodar seed, Davana, Sweet Marjoram and Pudina. Indian Perfum 28 (1): 10-6 (1984)] A presentation of Indian essential oils from a variety of sources.

Synonyms and Identifiers:

Synonyms:

CEDAR OIL
**PEER REVIEWED**

Cedarwood oil (Virginia)
**PEER REVIEWED**

Cedrus atlantica oil
**PEER REVIEWED**

Oil cedar
**PEER REVIEWED**

OIL OF CEDARWOOD
**PEER REVIEWED**

Oils, cedarwood
**PEER REVIEWED**

Red cedarwood oil
**PEER REVIEWED**

RTECS Number:

NIOSH/FJ1520050

Administrative Information:

Hazardous Substances Databank Number: 1972
Last Revision Date: 20010809
Last Review Date: Reviewed by SRP on 9/29/1994
Update History:

Complete Update on 08/09/2001, 1 field added/edited/deleted.
Complete Update on 05/15/2001, 1 field added/edited/deleted.
Complete Update on 06/12/2000, 1 field added/edited/deleted.
Complete Update on 03/09/2000, 1 field added/edited/deleted.
Complete Update on 02/08/2000, 1 field added/edited/deleted.
Complete Update on 02/02/2000, 1 field added/edited/deleted.
Complete Update on 11/18/1999, 1 field added/edited/deleted.
Complete Update on 09/21/1999, 1 field added/edited/deleted.
Complete Update on 08/26/1999, 1 field added/edited/deleted.
Complete Update on 06/02/1998, 1 field added/edited/deleted.
Complete Update on 02/27/1998, 1 field added/edited/deleted.
Complete Update on 10/26/1997, 1 field added/edited/deleted.
Complete Update on 01/27/1997, 1 field added/edited/deleted.
Complete Update on 05/10/1996, 1 field added/edited/deleted.
Complete Update on 01/23/1996, 1 field added/edited/deleted.
Complete Update on 08/21/1995, 1 field added/edited/deleted.
Complete Update on 04/25/1995, 1 field added/edited/deleted.
Complete Update on 01/12/1995, 24 fields added/edited/deleted.
Field Update on 12/28/1994, 1 field added/edited/deleted.
Complete Update on 03/25/1994, 1 field added/edited/deleted.
Field update on 12/23/1992, 1 field added/edited/deleted.
Field update on 03/06/1990, 1 field added/edited/deleted.
Complete Update on 04/30/1986

Record Length: 43300