GERANIOL
Human Health Effects:
Human Toxicity Excerpts:
SEE OIL OF CITRONELLA... VOMITING, SHOCK, CYANOSIS & CONVULSIONS PRECEDED DEATH IN
CHILD WHO CONSUMED UNKNOWN QUANTITY OF COMMERCIAL PREPARATION CONSISTING LARGELY OF OIL OF
CITRONELLA /WHICH CONTAINS 93% GERANIOL/.
GASTRIC MUCOSA WAS FOUND TO BE SEVERELY DAMAGED. /OIL OF CITRONELLA/
Minimum Fatal Dose Level:
3(?). 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ
AND 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB).
Emergency Medical Treatment:
Emergency Medical Treatment:
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reference. THE COMPLETE POISINDEX(R) DATABASE, AVAILABLE FROM MICROMEDEX, SHOULD BE
CONSULTED FOR ASSISTANCE IN THE DIAGNOSIS OR TREATMENT OF SPECIFIC CASES. Copyright
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replication or redistribution of all or part of the POISINDEX(R) database is a violation
of Micromedex' copyrights and is strictly prohibited. The following Overview, *** LEMON GRASS OIL ***, is relevant for this HSDB record chemical. |
| Life Support: |
o This overview assumes that basic life support measures
have been instituted.
|
| Clinical Effects: |
SUMMARY OF EXPOSURE
o The primary effect seen of this oil is irritation,
especially contact or allergic dermatitis. Systemic
symptoms in humans are unusual.
HEENT
o May be irritating to the mucous membranes of the mouth
and throat.
NEUROLOGIC
o Citral (the main constituent of lemon grass oil) may
have a sedative effect.
HEPATIC
o Citral has caused a 25% increase in liver enzyme
activity in laboratory animals.
DERMATOLOGIC
o Citral is a primary skin irritant and sensitizing agent
in concentrations of greater than 8%.
|
| Laboratory: |
o There are no useful laboratory measures. |
| Treatment Overview: |
ORAL/PARENTERAL EXPOSURE
o Lemon grass oil may be an aspiration risk. Emesis is
NOT recommended. Gastric decontamination is probably
not necessary for amounts less than 1 mL/kg. For
amounts in excess of 1 mL/kg, activated charcoal may be
considered.
o ACTIVATED CHARCOAL: Administer charcoal as slurry (240
mL water/30 g charcoal). Usual dose: 25 to 100 g in
adults/adolescents, 25 to 50 g in children (1 to 12
years), and 1 g/kg in infants less than 1 year old.
o SEDATION - Although CNS depression has been reported in
both man and animals, serious coma has not yet been
seen. If coma ensues, respiratory support may be
necessary.
EYE EXPOSURE
o DECONTAMINATION: Irrigate exposed eyes with copious
amounts of tepid water for at least 15 minutes. If
irritation, pain, swelling, lacrimation, or photophobia
persist, the patient should be seen in a health care
facility.
DERMAL EXPOSURE
o Irrigate all areas contacted by lemon grass oil with
cool water. Warm or hot water may increase the
incidence and severity of dermal reactions.
|
| Range of Toxicity: |
o Therapeutic Dose - 500 mcg/kg is an acceptable daily
intake for citral.
o A human toxic dose for citral has not been established.
|
Animal Toxicity Studies:
Metabolism/Pharmacokinetics:
Pharmacology:
Minimum Fatal Dose Level:
3(?). 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ
AND 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB).
Environmental Fate & Exposure:
Natural Pollution Sources:
/IT IS FOUND IN/...LAVENDER, JASMINE, CORIANDER, CARROT, MYRRH, EUCALYPTUS, LINALOE,
LIME, MANDARIN PETITGRAIN, BERGAMOT PETITGRAIN, BERGAMOT, LEMON, ORANGE, & OTHERS.
Environmental Standards & Regulations:
FDA Requirements:
FDA SECTION NUMBER 121.101; GRAS, SYNTHETIC FLAVOR & ADJUVANT.
Chemical/Physical Properties:
Molecular Formula:
C10-H18-O
Molecular Weight:
154.24
Color/Form:
COLORLESS TO PALE YELLOW
OILY LIQUID
Odor:
SWEET ROSE ODOR
PLEASANT GERANIUM ODOR
SWEET, FLORAL ODOR
Taste:
FRUITY APPLE TASTE
Boiling Point:
230 DEG C @ 760 MM HG
Melting Point:
LESS THAN -15 DEG C
Density/Specific Gravity:
0.8894 @ 20 DEG C
Solubilities:
PRACTICALLY INSOL IN WATER
SOL IN 70% ETHANOL 1:2 AND IN MOST ORGANIC SOLVENTS
SOL IN ETHER, ACETONE
MISCIBLE WITH ALCOHOL
water solubility = 100 mg/L @ 25 deg C
Spectral Properties:
INDEX OF REFRACTION: 1.4766 @ 20 DEG C/D; MAX ABSORPTION (ALC): 215 NM (LOG E= 3.25);
238 NM (LOG E= 2.30); 325 NM SHOULDER
INDEX OF REFRACTION: 1.4690-1.4780 @ 20 DEG C; 1.47773 @ 20 DEG C; OPTICAL ROTATION: -2
DEG TO +2 DEG @ 0 DEG C
MAX ABSORPTION: 190-195 NM (E= 18,000)
IR: 8087 (Sadtler Research Laboratories Prism Collection)
UV: 6-315 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New
York)
NMR: 279 (Varian Associates NMR Spectra Catalogue)
MASS: 939 (Atlas of Mass Spectral Data, John Wiley & Sons, New York)
Other Chemical/Physical Properties:
SWEET, FRAGRANT ODOR, LIQUID /ACETATE/
Chemical Safety & Handling:
Flash Point:
101 DEG C
Occupational Exposure Standards:
Manufacturing/Use Information:
Major Uses:
IN SOAPS & COSMETICS
PERFUMERY
ATTRACTANT FOR JAPANESE BEETLE
Manufacturers:
Elan Chemical Co, Hq, 268 Doremus Ave, Newark, NJ 07105, (201) 344-8014
Givaudan Corp, Hq, 100 Delawanna Ave, Clifton, NJ 07014, (201) 365-8000; Chemicals
Division; Production site: Clifton, NJ 07014
Hanson PLC, Hq, 100 Wood Ave S, Iselin, NJ 08830, (201) 549-7050; SCM Corp, 299 Park
Ave, New York, NY 10171-0161; SCM GLIDCO Organics Group, PO Box 389, Jacksonville, FL
32201; Production sites: Brunswick, GA 31520; Foot of West 61st St, Jacksonville, FL 32208
International Flavors & Fragrances, Inc, Hq, 521 West 57th Street, New York, NY
10019, (212) 765-5500; Production site: 800 Rose Lane, Union Beach, NJ 07735
Ungerer & Co, Hq, 4 Bridgewater Lane, Lincoln Park, NJ 07035, (201) 628-0600;
Chemical Division, 650 Union Blvd, Totowa, NJ 07512
Unilever United States, Inc, Hq, 390 Park Ave, New York, NY 10022, (212) 888-1260;
Quest International, 400 International Dr, Mt Olive, NJ 07828; Production site: Fanny Rd,
Boonton, NJ 07005
Union Camp Corp, Hq, 1600 Valley Rd, Wayne, NJ 07470, (201) 628-2000; BBA Aroma
Chemicals; Production site: Jacksonville, FL 32236
Methods of Manufacturing:
ISOLATION: JACOBSEN, ANN 157, 234 (1871). ... SYNTHESIS: BURRELL ET AL, J CHEM SOC (C)
2144 (1966).
BY FRACTIONAL DISTILLATION FROM...ESSENTIAL OILS RICH IN GERANIOL,
OR SYNTHETICALLY FROM MYRCENE.
DERIVED CITRONELLA-FREE GRADES FROM PALMEROSA OIL & SYNTHETICALLY FROM PINENE.
THESE ARE HIGHER QUALITY.
General Manufacturing Information:
AN OLEFINIC TERPENE ALCOHOL CONSTITUTING THE CHIEF PART OF OIL OF ROSE & OIL OF
PALMAROSA; ALSO FOUND IN MANY OTHER ESSENTIAL OILS SUCH AS CITRONELLA, LEMON GRASS, ETC.
PHYSICAL CONSTANTS VARY FOR VARIOUS COMMERCIAL PRODUCTS, DEPENDING ON TOTAL GERANIOL CONTENT. SPECIFIC GRAVITY & REFRACTIVE
INDEX MAY BE INDICATIVE OF PURITY OF THE PRODUCT.
USED IN COMPOUNDING ARTIFICIAL ATTAR OF ROSE /BUTYRATE/
CONSTITUENT OF ARTIFICIAL NEROLI OIL & OF ARTIFICIAL ORANGE BLOSSOM OIL /FORMATE/
GERANIOL WAS FULLY EFFECTIVE IN CHECKING
GROWTH OF BLUE MOLD (PENICILLIUM ITALICUM) IN MANDARIN ORANGES.
USEFUL IN APPLE, PEACH, STRAWBERRY, APRICOT, CITRUS SYNTHETIC FLAVORS
REPORTED USES INCLUDE 2.1 PPM IN NON-ALCOHOLIC BEVERAGES; 3.3 PPM IN ICE CREAM, ICES,
ETC; 10 PPM IN CANDY; 11 PPM IN BAKED GOODS; 2.0 PPM IN GELATINS & PUDDINGS; 0.80-2.9
PPM IN CHEWING GUM; 1.0 PPM IN TOPPINGS.
WHEN TESTED IN VITRO AGAINST 6 PENICILLIUM AND 5 FUSARIUM SPECIES, GERANIOL
WAS MOST EFFECTIVE IN FUNGICIDAL ACTIVITY.
GERANIOL INHIBITED THE FUNGUS ASCOSPHAERA
APIS, WHICH CAUSES CHALKBROOD DISEASE IN THE HONEYBEE APIS MELLIFERA
.../IT IS/ REPORTED IN MORE THAN 160 ESSENTIAL OILS: GINGER GRASS, LEMONGRASS, CEYLON
& JAVA CITRONELLA, TUBEROSE, OAK MUSK, ORRIS, CHAMPACA, YLANG-YLANG, MACE, NUTMEG,
SASSAFRAS, CAJENNE BOIS-DE-ROSE, ROSE, ACACIA FARNESIANA, GERANIUM, CLARY SAGE, SPIKE,
LAVANDIN... ESSENTIAL OILS OF PALMAROSA & CYMBOPOGON WINTERIANUS CONTAIN HIGHEST
LEVELS...(APPROX 80-95%).
GERANIOL IS COMPD IN NATURAL COCOA AROMA.
CITRONELLA GRASS FROM CEYLON CONTAINS 29-39% GERANIOL;
CITRONELLA GRASS FROM JAVA CONTAINS 26-45% GERANIOL,
CAMPHENE, LINALOOL, PINENE, & CINEOL.
FEMA NUMBER 2507
Formulations/Preparations:
GRADES: STANDARD; SOAP; SYNTHETIC; FCC; EOA.
COMMERCIAL PRODUCT CONTAINS 88% MINIMUM GERANIOL.
ESTER CONTENT IS NOT MORE THAN 1% (AS GERANYL ACETATE). ALDEHYDE CONTENT IS NOT MORE THAN
1% (AS CITRONELLOL). /FROM TABLE/
Laboratory Methods:
Analytic Laboratory Methods:
PRODUCT ANALYSIS: COMMERCIAL GERANIOL CANNOT
BE CLASSIFIED ACCORDING TO ITS ALCOHOL CONTENT AS MOST OF RECURRING IMPURITIES ARE
ALCOHOLIC IN NATURE (NEROL, CITRONELLOL, TETRAHYDROGERANIOL). GAS-CHROMATOGRAPHY
TECHNIQUES MAY BE USEFULLY EMPLOYED TO DETERMINE GERANIOL
CONTENT IN PRODUCT.
THE ESSENTIAL OIL OF GUTIERREZIA SAROTHRAE (BROOMWEED) IDENTIFIED BY GAS
CHROMATOGRAPHY--MASS SPECTROMETRY INCLUDED GERANIOL.
Special References:
Synonyms and Identifiers:
Synonyms:
(E)-3,7-DIMETHYL-2,6-OCTADIEN-1-OL
**PEER REVIEWED**
2-TRANS-3,7-DIMETHYL-2,6-OCTADIEN-1-OL
**PEER REVIEWED**
2,6-DIMETHYL-TRANS-2,6-OCTADIEN-8-OL
**PEER REVIEWED**
3,7-DIMETHYL-TRANS-2,6-OCTADIEN-1-OL
**PEER REVIEWED**
2,6-DIMETHYL-2,6-OCTADIEN-8-OL
**PEER REVIEWED**
3,7-DIMETHYL-2,6-OCTADIEN-1-OL
**PEER REVIEWED**
TRANS-GERANIOL
**PEER REVIEWED**
GERANIOL ALCOHOL
**PEER REVIEWED**
GERANIOL EXTRA
**PEER REVIEWED**
GERANYL ALCOHOL
**PEER REVIEWED**
GUANIOL
**PEER REVIEWED**
LEMONOL
**PEER REVIEWED**
2,6-OCTADIEN-1-OL, 3,7-DIMETHYL-, (E)-
**PEER REVIEWED**
2,6-OCTADIEN-1-OL, 3,7-DIMETHYL-, TRANS-
**PEER REVIEWED**
Formulations/Preparations:
GRADES: STANDARD; SOAP; SYNTHETIC; FCC; EOA.
COMMERCIAL PRODUCT CONTAINS 88% MINIMUM GERANIOL.
ESTER CONTENT IS NOT MORE THAN 1% (AS GERANYL ACETATE). ALDEHYDE CONTENT IS NOT MORE THAN
1% (AS CITRONELLOL). /FROM TABLE/
RTECS Number:
NIOSH/RG5830000
Administrative Information:
Hazardous Substances Databank Number: 484
Last Revision Date: 20010808
Update History:
Field Update on 08/08/2001, 1 field added/edited/deleted.
Field Update on 05/15/2001, 1 field added/edited/deleted.
Complete Update on 02/02/2000, 1 field added/edited/deleted.
Complete Update on 09/21/1999, 1 field added/edited/deleted.
Complete Update on 08/26/1999, 1 field added/edited/deleted.
Complete Update on 06/02/1998, 1 field added/edited/deleted.
Complete Update on 03/25/1998, 4 fields added/edited/deleted.
Field Update on 02/25/1998, 1 field added/edited/deleted.
Field Update on 10/17/1997, 1 field added/edited/deleted.
Field Update on 05/10/1996, 1 field added/edited/deleted.
Field Update on 01/19/1996, 1 field added/edited/deleted.
Field Update on 12/21/1994, 1 field added/edited/deleted.
Field Update on 11/03/1994, 1 field added/edited/deleted.
Field Update on 11/02/1994, 1 field added/edited/deleted.
Complete Update on 11/01/1993, 1 field added/edited/deleted.
Field update on 12/13/1992, 1 field added/edited/deleted.
Complete Update on 10/10/1990, 1 field added/edited/deleted.
Complete Update on 04/16/1990, 1 field added/edited/deleted.
Field update on 12/29/1989, 1 field added/edited/deleted.
Complete Update on 12/14/1984
Record Length: 29785